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Publications

{slider=Ressources audiovisuelles}

Bien nourrir son cerveau

Bien nourrir son cerveau
Quels sont les effets de l’alimentation sur nos humeurs et nos capacités intellectuelles ?

De Cork à Melbourne en passant par Bordeaux ou Lübeck, ce documentaire dresse un panorama des récentes découvertes concernant l’impact de l’alimentation sur les méninges. Au fil d’interviews de spécialistes, d’animations didactiques et d’expériences en laboratoire, il décortique les mécanismes à l’œuvre dans cette étonnante relation et livre de précieux enseignements pour faire de notre assiette une alliée de notre santé mentale.

Un captivant tour d’horizon des découvertes de la neuro-nutrition avec notamment les travaux de Serge Ahmed (IMN), Xavier Fioramonti (NutriNeuro) et Sophie Layé (NutriNeuro).

A voir en ligne jusqu’au 19 novembre 2019, ou en rediffusion sur Arte.

https://www.arte.tv/fr/videos/082725-000-A/bien-nourrir-son-cerveau/

NutriNeuro et NutriBrain dans l'émission Télématin sur France 2

NutriNeuro dans l'émission Télématin sur France 2
26/04/18 et 09/05/18

Dans le cadre de la page santé des émissions Télématin des 26/04 et 09/05/18, Anne-Laure Dinel parle des légumes à feuilles vertes et des troubles cognitifs liés à l'âge d'une part et des oméga-3 et anxiété d'autre part.

Comment la nutrition peut-elle protéger le cerveau ?

Comment la nutrition peut-elle protéger le cerveau ?
12-45 d'M6, 14/03/18

Dans le cadre de la semaine du cerveau, Anne-Laure Dinel parle de comment protéger le cerveau par la nutrition.

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{slider=Publications 2020}

  1. CHATAIGNER M, MORTESSAGNE P, LUCAS C, PALLET V, LAYE S, MEHAIGNERIE A, BOUVRET E, DINEL AL, JOFFRE C. (2020). Dietary fish hydrolysate supplementation containing n-3 LC-PUFAs and peptides prevents short-term memory and stress response deficits in aged mice. Brain Behav Immun Sep 23:S0889-1591(20)30743-1. doi: 10.1016/j.bbi.2020.09.022.
  2. DINEL AL., LUCAS C., GUILLEMET D., LAYE S., PALLET V., JOFFRE C. (2020). Chronic supplementation with a mix of Salvia officials and Salvia lavandulaefolia improves Morris water maze learning in normal adult C57Bl/6J mice. Nutrients 12: 1777. doi: 10.3390/nu12061777.
  3. JOFFRE C., DINEL A.L., CHATAIGNER M., PALLET V., LAYE S. (2020). N-3 polyunsaturated fatty acids and their derivates reduce neuroinflammation during aging. Nutrients, 12:647. doi: 10.3390/nu12030647.
  4. BAZINET RP, METHEREL AH, CHEN CT, SHAIKH SR, NADJAR A, JOFFRE C, LAYE S (2020). Brain eicosapentaenoic acid metabolism as a lead for novel therapeutics in major depression. Brain Behav Immun. 85:21-28. doi: 10.1016/j.bbi.2019.07.001.

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{slider=Publications 2019}

  1. DINEL AL, GUINOBERT I, LUCAS C., BLONDEAU C., BARDOT V., RIPOCHE I, BERTHOMIER L, PALLET, V., LAYE S., JOFFRE C (2019). Reduction of acute mild stress corticosterone response and changes in stress-responsive gene expression in male Balb/c mice after repeated administration of a Rhodiola rosea L. root extract. Food Sci Nutr 7: 3827-3841. doi: 10.1002/fsn3.1249
  2. JOFFRE C, REY C, LAYE S (2019). N-3 Polyunsaturated Fatty Acids and the Resolution of Neuroinflammation. Front Pharmacol. 10:1022. doi: 10.3389/fphar.2019.01022.
  3. REY CDELPECH JC, MADORE C, NADJAR A, GREENHALGH AD, AMADIEU C, AUBERT A, PALLET V, VAYSSE C, LAYE S, JOFFRE C (2019). Dietary n-3 long chain PUFA supplementation promotes a pro-resolving oxylipin profile in the brain. Brain Behav Immun. 76:17-27. doi: 10.1016/j.bbi.2018.07.025.
  4. BENSALEM J, DUDONNE S, ETCHAMENDY N, PELLAY H, AMADIEU C, GAUDOUT D, DUBREUIL S, PARADIS ME, POMERLEAU S, CAPURON L, HUDON C, LAYE S, DESJARDINS Y, PALLET V (2019). Polyphenols From Grape and Blueberry Improve Episodic Memory in Healthy Elderly with Lower Level of Memory Performance: A Bicentric D""Blind, Randomized, Placebo-Controlled Clinical Study.J Gerontol A Biol Sci Med Sci. 74(7):996-1007. doi: 10.1093/gerona/gly166.

 

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{slider=Publications 2018}

  1. JOFFRE C, DINEL ANNE-LAURE, LAYE S. (2018) Neuro-inflammation dans les maladies neurologiques. Rôle des probiotiques. Phytothérapie 16:326-335.
  2. LARRIEU T, LAYE S. Food for mood: Relevance of Nutritional Omega-3 Fatty Acids for Depression and AnxietyFront Physiol. 9:1047.
  3.  BENSALEM J, DUDONNE S, ETCHAMENDY N, PELLAY H, AMADIEU C, GAUDOUT D, DUBREUIL S, PARADIS ME, POMERLEAU S, CAPURON L, HUDON C,LAYE S, DESJARDINS Y, PALLET V. Polyphenols from grape and blueberry improve episodic memory in healthy elderly with lower level of memory performance: a bicentric double-blind, randomized, placebo-controlled clinical study.J Gerontol A Biol Sci Med Sci. 2018 Jul 19
  4. BENSALEM J, DUDONNE S, GAUDOUT D, SERVANT L, CALON F, DESJARDINS Y, LAYE S, LAFENETRE P, PALLET V. Polyphenol-rich extract from grape and blueberry attenuates cognitive decline and improves neuronal function in aged mice.J Nutr Sci. 7:e19.
  5. LABROUSSE VF, LEYROLLE Q, AMADIEU C, AUBERT A, SERE A, COUTUREAU E, GREGOIRE S, BRETILLON L, PALLET V, GRESSENS P, JOFFRE C, NADJAR A, LAYE S. Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation. Brain Behav Immun. 2018 Jun 4.
  6. REY C, NADJAR A, JOFFRE F, AMADIEU C, AUBERT A, VAYSSE C, PALLET V, LAYÉ S, JOFFRE C. Maternal n-3 polyunsaturated fatty acid dietary supply modulates microglia lipid content in the offspringProstaglandins Leukot Essent Fatty Acids. 133:1-7.
  7. LAYE S, NADJAR N., JOFFRE C., BAZINET RP (2018). Anti-inflammatory effects of omega-3 fatty acids in the brain: physiological mechanisms and relevance to pharmacologyPharm Rev 70:12-38.

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{slider=Publications 2017}

  1. TANTOT F, PARKES SL, MARCHAND AR, BOITARD C, NANEIX F, LAYÉ S, TRIFILIEFF P, COUTUREAU E, FERREIRA G(2017). The effect of high-fat diet consumption on appetitive instrumental behavior in rats. Appetite 108:203-211.

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{slider=Publications 2016}

  1. BOSCH-BOUJU C, LARRIEU T, LINDERS L, MANZONI OJ, LAYE S. (2016). Endocannabinoid-Mediated Plasticity in Nucleus Accumbens Controls Vulnerability to Anxiety after Social Defeat Stress. Cell Rep. 16:1237-42.
  2. LÉTONDOR A, BUAUD B, VAYSSE C, RICHARD E, LAYÉ S, PALLET V, ALFOS S. (2016) EPA/DHA and Vitamin A Supplementation Improves Spatial Memory and Alleviates the Age-related Decrease in Hippocampal RXRγ and Kinase Expression in Rats. Front Aging Neurosci. 2016 May 9;8:103.
  3. NADJAR A, LEYROLLE Q, JOFFRE C, LAYE S. (2016). Bioactive lipids as new class of microglial modulators: When nutrition meets neuroimunology. Prog Neuropsychopharmacol Biol Psychiatry, in press.
  4. DINEL AL, REY C, BONHOMME C, LE RUYET P, JOFFRE C, LAYÉ S. (2016) Dairy fat blend improves brain DHA and neuroplasticity and regulates corticosterone in mice. Prostaglandins Leukot Essent Fatty Acids. 2016 Jun;109:29-38.
  5. THOMAZEAU A, BOSCH-BOUJU C, MANZONI O, LAYÉ S.(2016) Nutritional n-3 PUFA Deficiency Abolishes Endocannabinoid Gating of Hippocampal Long-Term Potentiation. Cereb Cortex. 2016 Mar 5.
  6. BENSALEMJ, SERVANTL, ALFOSS, GAUDOUT D, LAYÉ S, PALLET V, LAFENETREP. (2016) Dietary Polyphenol Supplementation Prevents Alterations of Spatial Navigation in Middle-Aged Mice.Front Behav Neurosci. 2016 Feb 9;10:9.
  7. HAMER M, DYE L, SIOBHAN MITCHELL E, LAYÉ S, SAUNDERS C, BOYLE N, SCHUERMANS J, SIJBEN (2016) Examining techniques for measuring the effects of nutrients on mental performance and mood state. J. Eur J Nutr. 2016 Jan 7.
  8. REY C, NADJAR A, BUAUD B, VAYSSE C, AUBERT A, PALLET V, LAYÉ S, JOFFRE C. Resolvin D1 and E1 promote resolution of inflammation in microglial cells in vitro. Brain Behav Immun. 2015 Dec 21.S0889-1591(15)30075-1.
  9. LARRIEU T, HILAL ML, DE SMEDT-PEYRUSSE V, SANS N, LAYÉ S. Glucocorticoid Receptor-Signaling Pathway and Neuronal Morphology in Regionally Distinct Brain Structures Associated with Emotional Deficits. Neural Plasticity. 2016.

{/slider}

{slider=Publications 2015}

  1. VAUZOUR D, MARTINSEN A, LAYE; S.. Neuroinflammatory processes in cognitive disorders: Is there a role for flavonoids and n-3 polyunsaturated fatty acids in counteracting their detrimental effects? Neurochem Int. 2015 89:63-74.
  2. CASTANON N, LUHESHI G, LAYE; S. Role of neuroinflammation in the emotional and cognitive alterations displayed by animal models of obesity. Front Neurosci. 2015 9:229.
  3. DELPECH JC, THOMAZEAU A, MADORE C, BOSCH-BOUJU C, LARRIEU T, LACABANNE C, REMUS-BOREL J, AUBERT A, JOFFRE C, NADJAR A, LAYE; S. Dietary n-3 PUFAs Deficiency Increases Vulnerability to Inflammation-Induced Spatial Memory Impairment. Neuropsychopharmacology. 2015 May 7.
  4. LEPINAY AL, LARRIEU T, JOFFRE C, ACAR N, GERATE I, CASTANON N, FERREIRA G, LANGELIER B, GUESNET P, BRETILLON L, PARNET P, LAYE S, DARNAUDERY M. Perinatal high-fat diet increases hippocampal vulnerability to the adverse effects of subsequent high-fat feeding..Psychoneuroendocrinology. 2015 Mar;53:82-93. doi: 10.1016/j.psyneuen.2014.12.008. Epub 2014 Dec 15.
  5. DELPECH JC, MADORE C, JOFFRE C, AUBERT A, KANG JX, NADJAR A, LAYE; S. Transgenic increase in n-3/n-6 fatty acid ratio protects against cognitive deficits induced by an immune challenge through decrease of neuroinflammation. Neuropsychopharmacology. 2015 40(3):525-36.
  6. JOFFRE F, VAUTIER V, BARAT P. [Determinants of participation in a program for diabetes education in children]. Arch Pediatr. 2015 Jun;22(6):677-8. (Review), IF 0.343

{/slider}
{slider=Publications 2014}

  1. LEPINAY AL, LARRIEU T, JOFFRE C, ACAR N, GERATE I, CASTANON N, FERREIRA G, LANGELIER B, GUESNET P, BRETILLON L, PARNET P, LAYE S, DARNAUDÉRY M.. Perinatal high-fat diet increases hippocampal vulnerability to the adverse effects of subsequent high-fat feeding. Psychoneuroendocrinology. 2014 Dec15;53C:82-93
  2. RICHARD P. BAZINET AND SOPHIE LAYE. Polyunsaturated fatty acids and their metabolites in brain function and disease, Nat Rev Neurosci. 2014 Nov 12. See more at: http://www.neuroscience.univ-bordeauxsegalen.fr/
  3. PIETROPAOLO S, GOUBRAN MG, JOFFRE C, AUBERT A, LEMAIRE-MAYO V, CRUSIO WE, LAYE S. Dietary supplementation of omega-3 fatty acids rescues fragile X phenotypes in Fmr1-Ko mice. Psychoneuroendocrinology. 2014 Nov;49:119-29
  4. LETONDOR A, BUAUD B, VAYSSE C, FONSECA L, HERROUIN C, SERVAT B, LAYE; S, PALLET V, ALFOS S.Erythrocyte DHA level as a biomarker of DHA status in specific brain regions of n-3 long-chain PUFA-supplemented aged rats.Br J Nutr. 2014 Oct ; 21:1-14.
  5. LARRIEU T, HILAL LM, FOURRIER C, DE SMEDT-PEYRUSSE V, SANS N, CAPURON L, LAYE; S.Nutritional omega-3 modulates neuronal morphology in the prefrontal cortex along with depression-related behaviour through corticosterone secretion.Transl Psychiatry. 2014 Sep 9;4:e437.
  6. DELPECH JC, MADORE C, JOFFRE C, AUBERT A, KANG JX, NADJAR A, LAYE S. Transgenic Increase in n-3/n-6 Fatty Acid Ratio Protects Against Cognitive Deficits Induced by an Immune Challenge through Decrease of Neuroinflammation. Neuropsychopharmacology.2014 Aug 5 2014 Jul;30(5):405-14.
  7. MADORE C, NADJAR A, DELPECH JC, SERE A, AUBERT A, PORTAL C, JOFFRE C, LAYE S.Nutritional n-3 PUFAs deficiency during perinatal periods alters brain innate immune system and neuronal plasticity-associated genes. Brain Behav Immun. 2014 Epub Apr 13.
  8. ANDRE C, DINEL AL, FERREIRA G, LAYE; S, CASTANON N. Diet-induced obesity progressively alters cognition, anxiety-like behavior and lipopolysaccharide-induced depressive-like behavior: Focus on brain indoleamine 2,3-dioxygenase activation. 2014 Brain Behav Immun. 41, 10-21.
  9. BONHOMME D, MINNI AM, ALFOS S, ROUX P, RICHARD E, HIGUERET P, MOISAN MP, PALLET V, TOUYAROT K. Vitamin A status regulates glucocorticoid availability in Wistar rats: consequences on cognitive functions and hippocampal neurogenesis ? Front Behav Neurosci. 2014 Feb 4;8:20
  10. BONHOMME D, PALLET V, DOMINGUEZ G, SERVANT L, HENKOUS N, LAFENETRE P, HIGUERET P, BERACOCHEA D, TOUYAROT K. Retinoic acid modulates intrahippocampal levels of corticosterone in middle-aged mice: consequences on hippocampal plasticity and contextual memory. Front Aging Neurosci. 2014 Feb 7;6:6.
  11. DINEL AL, ANDRE C, AUBERT A, FERREIRA G, LAYE S,CASTANON N. Lipopolysaccharide-induced brain activation of the indoleamine 2,3-dioxygenase and depressive-like behavior are impaired in a mouse model of metabolic syndrome. Psychoneuroendocrinology Volume 40, February 2014, Pages 48–59

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{slider=Revues presse spécialisée}

A Paraitre : 60 millions de consommateur : Nutrition et cerveau

Article dans le Hors Serie Forme 2019 du journal Veggie Slowly

Article de presse sur le site "onmangequoi" de la mutuelle générale > Lire l'article..

Sur le site http://www.edp-nutrition.fr, Clémentine Bosh-Bouju et Sophie Layé "Fonctionnement Cérébral: Le rôle des acides gras polyinsaturés" (télécharger le document)

Recherche et Santé N°143 (FRM) « Les oméga-3 bons pour le moral »


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Bien nourrir son cerveau

Bien nourrir son cerveau
Quels sont les effets de l’alimentation sur nos humeurs et nos capacités intellectuelles ?

De Cork à Melbourne en passant par Bordeaux ou Lübeck, ce documentaire dresse un panorama des récentes découvertes concernant l’impact de l’alimentation sur les méninges. Au fil d’interviews de spécialistes, d’animations didactiques et d’expériences en laboratoire, il décortique les mécanismes à l’œuvre dans cette étonnante relation et livre de précieux enseignements pour faire de notre assiette une alliée de notre santé mentale.

Un captivant tour d’horizon des découvertes de la neuro-nutrition avec notamment les travaux de Serge Ahmed (IMN), Xavier Fioramonti (NutriNeuro) et Sophie Layé (NutriNeuro).

A voir en ligne jusqu’au 19 novembre 2019, ou en rediffusion sur Arte.

https://www.arte.tv/fr/videos/082725-000-A/bien-nourrir-son-cerveau/

NutriNeuro et NutriBrain dans l'émission Télématin sur France 2

NutriNeuro dans l'émission Télématin sur France 2
26/04/18 et 09/05/18

Dans le cadre de la page santé des émissions Télématin des 26/04 et 09/05/18, Anne-Laure Dinel parle des légumes à feuilles vertes et des troubles cognitifs liés à l'âge d'une part et des oméga-3 et anxiété d'autre part.

Comment la nutrition peut-elle protéger le cerveau ?

Comment la nutrition peut-elle protéger le cerveau ?
12-45 d'M6, 14/03/18

Dans le cadre de la semaine du cerveau, Anne-Laure Dinel parle de comment protéger le cerveau par la nutrition.

  1. CHATAIGNER M, MORTESSAGNE P, LUCAS C, PALLET V, LAYE S, MEHAIGNERIE A, BOUVRET E, DINEL AL, JOFFRE C. (2020). Dietary fish hydrolysate supplementation containing n-3 LC-PUFAs and peptides prevents short-term memory and stress response deficits in aged mice. Brain Behav Immun Sep 23:S0889-1591(20)30743-1. doi: 10.1016/j.bbi.2020.09.022.
  2. DINEL AL., LUCAS C., GUILLEMET D., LAYE S., PALLET V., JOFFRE C. (2020). Chronic supplementation with a mix of Salvia officials and Salvia lavandulaefolia improves Morris water maze learning in normal adult C57Bl/6J mice. Nutrients 12: 1777. doi: 10.3390/nu12061777.
  3. JOFFRE C., DINEL A.L., CHATAIGNER M., PALLET V., LAYE S. (2020). N-3 polyunsaturated fatty acids and their derivates reduce neuroinflammation during aging. Nutrients, 12:647. doi: 10.3390/nu12030647.
  4. BAZINET RP, METHEREL AH, CHEN CT, SHAIKH SR, NADJAR A, JOFFRE C, LAYE S (2020). Brain eicosapentaenoic acid metabolism as a lead for novel therapeutics in major depression. Brain Behav Immun. 85:21-28. doi: 10.1016/j.bbi.2019.07.001.

  1. DINEL AL, GUINOBERT I, LUCAS C., BLONDEAU C., BARDOT V., RIPOCHE I, BERTHOMIER L, PALLET, V., LAYE S., JOFFRE C (2019). Reduction of acute mild stress corticosterone response and changes in stress-responsive gene expression in male Balb/c mice after repeated administration of a Rhodiola rosea L. root extract. Food Sci Nutr 7: 3827-3841. doi: 10.1002/fsn3.1249
  2. JOFFRE C, REY C, LAYE S (2019). N-3 Polyunsaturated Fatty Acids and the Resolution of Neuroinflammation. Front Pharmacol. 10:1022. doi: 10.3389/fphar.2019.01022.
  3. REY CDELPECH JC, MADORE C, NADJAR A, GREENHALGH AD, AMADIEU C, AUBERT A, PALLET V, VAYSSE C, LAYE S, JOFFRE C (2019). Dietary n-3 long chain PUFA supplementation promotes a pro-resolving oxylipin profile in the brain. Brain Behav Immun. 76:17-27. doi: 10.1016/j.bbi.2018.07.025.
  4. BENSALEM J, DUDONNE S, ETCHAMENDY N, PELLAY H, AMADIEU C, GAUDOUT D, DUBREUIL S, PARADIS ME, POMERLEAU S, CAPURON L, HUDON C, LAYE S, DESJARDINS Y, PALLET V (2019). Polyphenols From Grape and Blueberry Improve Episodic Memory in Healthy Elderly with Lower Level of Memory Performance: A Bicentric D""Blind, Randomized, Placebo-Controlled Clinical Study.J Gerontol A Biol Sci Med Sci. 74(7):996-1007. doi: 10.1093/gerona/gly166.

 

  1. JOFFRE C, DINEL ANNE-LAURE, LAYE S. (2018) Neuro-inflammation dans les maladies neurologiques. Rôle des probiotiques. Phytothérapie 16:326-335.
  2. LARRIEU T, LAYE S. Food for mood: Relevance of Nutritional Omega-3 Fatty Acids for Depression and AnxietyFront Physiol. 9:1047.
  3.  BENSALEM J, DUDONNE S, ETCHAMENDY N, PELLAY H, AMADIEU C, GAUDOUT D, DUBREUIL S, PARADIS ME, POMERLEAU S, CAPURON L, HUDON C,LAYE S, DESJARDINS Y, PALLET V. Polyphenols from grape and blueberry improve episodic memory in healthy elderly with lower level of memory performance: a bicentric double-blind, randomized, placebo-controlled clinical study.J Gerontol A Biol Sci Med Sci. 2018 Jul 19
  4. BENSALEM J, DUDONNE S, GAUDOUT D, SERVANT L, CALON F, DESJARDINS Y, LAYE S, LAFENETRE P, PALLET V. Polyphenol-rich extract from grape and blueberry attenuates cognitive decline and improves neuronal function in aged mice.J Nutr Sci. 7:e19.
  5. LABROUSSE VF, LEYROLLE Q, AMADIEU C, AUBERT A, SERE A, COUTUREAU E, GREGOIRE S, BRETILLON L, PALLET V, GRESSENS P, JOFFRE C, NADJAR A, LAYE S. Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation. Brain Behav Immun. 2018 Jun 4.
  6. REY C, NADJAR A, JOFFRE F, AMADIEU C, AUBERT A, VAYSSE C, PALLET V, LAYÉ S, JOFFRE C. Maternal n-3 polyunsaturated fatty acid dietary supply modulates microglia lipid content in the offspringProstaglandins Leukot Essent Fatty Acids. 133:1-7.
  7. LAYE S, NADJAR N., JOFFRE C., BAZINET RP (2018). Anti-inflammatory effects of omega-3 fatty acids in the brain: physiological mechanisms and relevance to pharmacologyPharm Rev 70:12-38.

  1. TANTOT F, PARKES SL, MARCHAND AR, BOITARD C, NANEIX F, LAYÉ S, TRIFILIEFF P, COUTUREAU E, FERREIRA G(2017). The effect of high-fat diet consumption on appetitive instrumental behavior in rats. Appetite 108:203-211.

  1. BOSCH-BOUJU C, LARRIEU T, LINDERS L, MANZONI OJ, LAYE S. (2016). Endocannabinoid-Mediated Plasticity in Nucleus Accumbens Controls Vulnerability to Anxiety after Social Defeat Stress. Cell Rep. 16:1237-42.
  2. LÉTONDOR A, BUAUD B, VAYSSE C, RICHARD E, LAYÉ S, PALLET V, ALFOS S. (2016) EPA/DHA and Vitamin A Supplementation Improves Spatial Memory and Alleviates the Age-related Decrease in Hippocampal RXRγ and Kinase Expression in Rats. Front Aging Neurosci. 2016 May 9;8:103.
  3. NADJAR A, LEYROLLE Q, JOFFRE C, LAYE S. (2016). Bioactive lipids as new class of microglial modulators: When nutrition meets neuroimunology. Prog Neuropsychopharmacol Biol Psychiatry, in press.
  4. DINEL AL, REY C, BONHOMME C, LE RUYET P, JOFFRE C, LAYÉ S. (2016) Dairy fat blend improves brain DHA and neuroplasticity and regulates corticosterone in mice. Prostaglandins Leukot Essent Fatty Acids. 2016 Jun;109:29-38.
  5. THOMAZEAU A, BOSCH-BOUJU C, MANZONI O, LAYÉ S.(2016) Nutritional n-3 PUFA Deficiency Abolishes Endocannabinoid Gating of Hippocampal Long-Term Potentiation. Cereb Cortex. 2016 Mar 5.
  6. BENSALEMJ, SERVANTL, ALFOSS, GAUDOUT D, LAYÉ S, PALLET V, LAFENETREP. (2016) Dietary Polyphenol Supplementation Prevents Alterations of Spatial Navigation in Middle-Aged Mice.Front Behav Neurosci. 2016 Feb 9;10:9.
  7. HAMER M, DYE L, SIOBHAN MITCHELL E, LAYÉ S, SAUNDERS C, BOYLE N, SCHUERMANS J, SIJBEN (2016) Examining techniques for measuring the effects of nutrients on mental performance and mood state. J. Eur J Nutr. 2016 Jan 7.
  8. REY C, NADJAR A, BUAUD B, VAYSSE C, AUBERT A, PALLET V, LAYÉ S, JOFFRE C. Resolvin D1 and E1 promote resolution of inflammation in microglial cells in vitro. Brain Behav Immun. 2015 Dec 21.S0889-1591(15)30075-1.
  9. LARRIEU T, HILAL ML, DE SMEDT-PEYRUSSE V, SANS N, LAYÉ S. Glucocorticoid Receptor-Signaling Pathway and Neuronal Morphology in Regionally Distinct Brain Structures Associated with Emotional Deficits. Neural Plasticity. 2016.

  1. VAUZOUR D, MARTINSEN A, LAYE; S.. Neuroinflammatory processes in cognitive disorders: Is there a role for flavonoids and n-3 polyunsaturated fatty acids in counteracting their detrimental effects? Neurochem Int. 2015 89:63-74.
  2. CASTANON N, LUHESHI G, LAYE; S. Role of neuroinflammation in the emotional and cognitive alterations displayed by animal models of obesity. Front Neurosci. 2015 9:229.
  3. DELPECH JC, THOMAZEAU A, MADORE C, BOSCH-BOUJU C, LARRIEU T, LACABANNE C, REMUS-BOREL J, AUBERT A, JOFFRE C, NADJAR A, LAYE; S. Dietary n-3 PUFAs Deficiency Increases Vulnerability to Inflammation-Induced Spatial Memory Impairment. Neuropsychopharmacology. 2015 May 7.
  4. LEPINAY AL, LARRIEU T, JOFFRE C, ACAR N, GERATE I, CASTANON N, FERREIRA G, LANGELIER B, GUESNET P, BRETILLON L, PARNET P, LAYE S, DARNAUDERY M. Perinatal high-fat diet increases hippocampal vulnerability to the adverse effects of subsequent high-fat feeding..Psychoneuroendocrinology. 2015 Mar;53:82-93. doi: 10.1016/j.psyneuen.2014.12.008. Epub 2014 Dec 15.
  5. DELPECH JC, MADORE C, JOFFRE C, AUBERT A, KANG JX, NADJAR A, LAYE; S. Transgenic increase in n-3/n-6 fatty acid ratio protects against cognitive deficits induced by an immune challenge through decrease of neuroinflammation. Neuropsychopharmacology. 2015 40(3):525-36.
  6. JOFFRE F, VAUTIER V, BARAT P. [Determinants of participation in a program for diabetes education in children]. Arch Pediatr. 2015 Jun;22(6):677-8. (Review), IF 0.343

  1. LEPINAY AL, LARRIEU T, JOFFRE C, ACAR N, GERATE I, CASTANON N, FERREIRA G, LANGELIER B, GUESNET P, BRETILLON L, PARNET P, LAYE S, DARNAUDÉRY M.. Perinatal high-fat diet increases hippocampal vulnerability to the adverse effects of subsequent high-fat feeding. Psychoneuroendocrinology. 2014 Dec15;53C:82-93
  2. RICHARD P. BAZINET AND SOPHIE LAYE. Polyunsaturated fatty acids and their metabolites in brain function and disease, Nat Rev Neurosci. 2014 Nov 12. See more at: http://www.neuroscience.univ-bordeauxsegalen.fr/
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